Publications

Selected publications and collaborative research contributions from the lab.

For a complete list of publications, visit PubMed.

Select Publications

Science Immunology · 2024

A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression

Plebanek MP, Xue Y, Nguyen YV, DeVito NC, Wang X, Holtzhausen A, Beasley GM, Theivanthiran B, Hanks BA.

Using single-cell transcriptomics and chromatin accessibility profiling, we investigate how inflammatory stress pathways alter dendritic cell function in tumor immunity.

PubMed

International Immunology · 2020

Role of dendritic cell metabolic reprogramming in tumor immune evasion

Plebanek MP, Sturdivant M, DeVito NC, Hanks BA

Defining transcriptional and epigenetic programs regulating myeloid cell differentiation in inflammatory disease.

PubMed

Molecular Cancer Therapeutics · 2018

Scavenger Receptor Type B1 and Lipoprotein Nanoparticle Inhibit Myeloid-Derived Suppressor Cells

Plebanek MP, Bhaumik D, Bryce PJ, Thaxton CS

Using single-cell transcriptomics and chromatin accessibility profiling, we investigate how inflammatory stress pathways alter dendritic cell function in tumor immunity.

PubMed

Nature Communications · 2017

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

Plebanek MP, Angeloni NL, Vinokour E, Li J, Henkin A, Martinez-Marin D, Filleur S, Bhowmick R, Henkin J, Miller SD, Ifergan I, Lee Y, Osman I, Thaxton CS, Volpert OV

Defining transcriptional and epigenetic programs regulating myeloid cell differentiation in inflammatory disease.

PubMed

Scientific Reports · 2015

Nanoparticle Targeting and Cholesterol Flux Through Scavenger Receptor Type B-1 Inhibits Cellular Exosome Uptake

Plebanek MP, Mutharasan RK, Volpert O, Matov A, Gatlin JC, Thaxton CS

Defining transcriptional and epigenetic programs regulating myeloid cell differentiation in inflammatory disease.

PubMed

Additional Publications

Collaborative and co-authored research contributions.

Cancer Research · 2025

GLI2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating WNT and Prostaglandin Signaling

DeVito NC, Nguyen YV, Sturdivant M, Plebanek MP, Villarreal KA, Yarla N, Jain V, Aksu M, Beasley GM, Theivanthiran B, Hanks BA

PubMed

Science Translational Medicine· 2022

Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti-PD-1 immunotherapy

Theivanthiran B, Yarla N, Haykal T, Nguyen YV, Cao L, Ferreira M, Holtzhausen A, Al-Rohil R, Salama AKS, Beasley GM, Plebanek MP, DeVito NC, Hanks BA

PubMed

Cell Reports · 2021

Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy

DeVito NC, Sturdivant M, Thievanthiran B, Xiao C, Plebanek MP, Salama AKS, Beasley GM, Holtzhausen A, Novotny-Diermayr V, Strickler JH, Hanks BA

PubMed

Journal of Extracellular Vesicles · 2020

Prostate cancer extracellular vesicles mediate intercellular communication with bone marrow cells and promote metastasis in a cholesterol-dependent manner

Henrich SE, McMahon KM, Plebanek MP, Calvert AE, Feliciano TJ, Parrish S, Tavora F, Mega A, De Souza A, Carneiro BA, Thaxton CS

PubMed

Journal of Clinical Investigation · 2020

A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy

Theivanthiran B, Evans KS, DeVito NC, Plebanek MP, Sturdivant M, Wachsmuth LP, Salama AK, Kang Y, Hsu D, Balko JM, Johnson DB, Starr M, Nixon AB, Holtzhausen A, Hanks BA

PubMed